Research Articles
2025
Oxidative stress and survival of Leishmania spp.: A relationship of inverse proportionality for disease outcome
Roy, S., Mandal, M., Halder, M., Das, P. K., and Ukil, A.
Expert reviews in molecular medicine. 2025 June 20:1-27.
Adenosine/A2AR/PKA signaling regulates HO-1-mediated anti-inflammatory responses during Leishmania donovani infection
Das T, Brahmachari P, and Ukil A.
mBio. 2025 Nov 24:e0258125.
2024
Antileishmanial activity of cathelicidin and its modulation by Leishmania donovani in a CREM-dependent manner for establishing infection
Roy S., Roy S., Banerjee M., Madbhagat P., Chande A., Ukil A.
The Journal of Infectious Diseases. 2024 March 27:jiae158.
Leishmania exploits host cAMP/EPAC/calcineurin signaling to induce an IL-33-mediated anti-inflammatory environment for the establishment of infection
Roy S., Roy S., Haldar S., Jana K., Ukil A.
Journal of Biological Chemistry. 2024 May 13:107366.
2023
PD-1 negatively regulates macrophage immune activation by turning off JNK and STAT1 signaling: Exploited by Leishmania for its intra-macrophage survival.
Roy S., Gupta A.K., Banerjee M., Das P.K. and Ukil A.
Cellular Immunology. 2023 Sep1; 391:104758.
2022
Mannose-Decorated Composite Peptide Hydrogel with Thixotropic and Syneresis Properties and its Application in Treatment of Leishmaniasis.
Dowari P, Roy S, Das S, Chowdhuri S, Kushwaha, R Das B, Ukil A and Das D.
Chem Asian J. 2022 Sep 14;17(18):e202200550.
Translationally Controlled Tumor Protein (TCTP) mediated stabilization of host anti-apoptotic protein MCL-1 is critical for establishment of infection by intra-macrophage parasite Leishmania donovani.
Giri J, Basu M, Roy S, Mishra T, Jana K, Chande A and Ukil A.
J Immunol. 2022 Jun 1;208(11):2540-2548.
Cytokines and signaling networks regulating disease outcomes in leishmaniasis.
Saha A, Roy S and Ukil A.
Infection and Immunity. 2022 Aug 18;90(8):e00248-22.
2021
Leishmania donovani targets host transcription factor NRF2 to activate anti-oxidant enzyme HO-1 and transcriptional repressor ATF3 for establishing infection.
Saha S, Dutta A, Jana K and Ukil A.
Infection and Immunity. 2021 Jun 16;89(7).
2020
Smart Thixotropic Hydrogels by Disulfide-Linked Short Peptides for Effective 3D Cell-Proliferation.
Chowdhuri, S, Saha A, Pramanik, B Das S, Dowari P, Ukil, A* and Das, D*
Langmuir. 2020 Dec 11;36(50):15450-62.
Spectrophotometric Assessment of Heme Oxygenase-1 Activity in Leishmania-infected 1 Macrophages.
Basu M, Saha S and Ukil A.
Bio-protocol. 2020 Apr 5;10(7):e3578-.
Increased host ATP efflux and its conversion to extracellular adenosine is crucial for establishing Leishmania infection.
Basu M, Gupta P, Dutta A, Jana K and Ukil A.
Journal of cell science. 2020 Apr 1;133(7):jcs239939.
2019
Autophagy protects peripheral blood mononuclear cells against inflammation, oxidative and nitrosative stress in diabetic dyslipidemia.
Chatterjee T, Pattanayak R, Ukil A, Chowdhury S and Bhattacharyya M
Free Radical Biology and Medicine. 2019 Nov 1;143:309-23.
Crosstalk of PD-1 signaling with SIRT1/FOXO-1 axis in progression of visceral leishmaniasis.
Roy S, SahaS, Gupta P, Ukil A and Das PK.
Journal of Cell Science. 2019 May 1;132(9):jcs226274.
Leishmania donovani exploits macrophage heme oxygenase-1 to neutralize oxidative burst and TLR signalling dependent host defense.
Saha S, Basu B, Guin S, RoyA, Gupta P, Mitterstiller AM, Weiss G, Jana K and Ukil A.
The Journal of Immunology. 2019 Feb 1;202(3):827-40.
2018
Multiple cross-linking strategy to form size tuneable bio-polymer with efficient cell adhesion and proliferation property.
Dowari P, Saha S, Pramanik B, Ahmed S, Singha N, *Ukil A and *Das D.
Biomacromolecules. 2018 Oct 8;19(10):3994-4002.
Recent advances in understanding Leishmania donovani infection: the importance of diverse host regulatory pathways.
Saha A, Basu M and Ukil A.
IUBMB life. 2018 Jul;70(7):593-601.
2017
Hydrogelation of a naphthalene diimide appended peptide amphiphile and its application in cell-imaging and intracellular pH sensing.
Singha N, Gupta P, Pramanik B, Ahmed S, *Dasgupta A, *Ukil A and *Das D.
Biomacromolecules. 2017 Nov 13;18(11):3630-41.
Leishmania donovani inhibits inflammasome-dependent macrophage activation by exploiting the negative regulatory proteins A20 and UCP2.
Gupta, AK, Ghosh, K, Palit S, Barua J, Das PK and Ukil A.
The FASEB Journal. 2017 Nov;31(11):5087-101.
The role of PD1 in regulation of macrophage apoptosis and its subversion by Leishmania donovani.
Roy S, Gupta P, Palit S, Basu M, Ukil A and Das PK.
Clinical & translational immunology. 2017 May;6(5):e137.
2016
Leishmania donovani inhibits macrophage apoptosis and pro-inflammatory response through AKT-mediated regulation of β-catenin and FOXO-1.
Gupta P, Srivastav S, Saha S, Das PK and Ukil A.
Cell Death & Differentiation. 2016 Nov;23(11):1815-26.
Leishmania donovani exploits myeloid cell leukemia 1 (MCL-1) protein to prevent mitochondria dependent host cell apoptosis.
Giri J, Srivastav S, Basu M, Palit S, Gupta P and Ukil A.
Journal of Biological Chemistry. 2016 Feb 12;291(7):3496-507.
2015
IRAK-M regulates the inhibition of TLR-mediated macrophage immune response late during in vitro Leishmania donovani infection.
Srivastav S, Saha A, Barua J, Ukil A and Das PK.
European journal of immunology. 2015 Oct;45(10):2787-97.
Antileishmanial effect of 18β-glycyrrhetinic acid is mediated by TLR dependent canonical and noncanonical p38 activation.
Gupta P, Das PK and Ukil A.
Antimicrobial agents and chemotherapy. 2015 May;59(5):2531-9.
2014
Prostaglandin E2 negatively regulates the production of Th1/Th17 cytokines and proinflammatory chemokines in visceral leishmaniasis.
Saha A, Biswas A, Srivastav S, Mukherjee M, Das PK and Ukil A.
The Journal of Immunology. 2014 Sep 1;193(5):2330-9.
Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response.
Gupta P, Giri J, Srivastav S, Chande AG, Mukhopadhyaya R, Das PK and Ukil A.
The FASEB Journal. 2014 Apr;28(4):1756-68.
Leishmania donovani prevents oxidative burst mediated apoptosis of host macrophages through selective induction of suppressors of cytokine signalling (SOCS) proteins.
Srivastav S, Basu Ball W, Gupta P, Giri J, Ukil A and Das PK.
Journal of Biological Chemistry. 2014 Jan 10;289(2):1092-105.
2013
Successful therapy of visceral leishmaniasis with curdlan involves T-helper 17 Cytokines.
Ghosh K, Sharma G, Saha A, Kar S, Das PK and Ukil A.
The Journal of infectious diseases. 2013 Mar 15;207(6):1016-25.
2012
2011
Curative effect of 18b-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases.
Ukil A, Kar S, Srivastav S, Ghosh K and Das PK.
PLoS one. 2011 Dec 14;6(12):e29062.
Cystatin cures visceral leishmaniasis by NF-kB mediated proinflammatory response through co-ordination of TLR/MyD88 signaling with p105-Tpl2-ERK pathway.
Kar S, Ukil A and Das PK.
European journal of immunology. 2011 Jan;41(1):116-27.
2010
MAPK directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms.
Kar S, Ukil A, Sharma G and Das PK.
Journal of leukocyte biology. 2010 Jul;88(1):9-20.
2009
Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kappaB and JAK/STAT pathways
*Kar S, *Ukil A and Das PK.
European journal of immunology. 2009 Mar;39(3):741-51.
Book chapters
Elucidating the strategies of immune evasion by Leishmania.
Srivastav S, Ukil A and Das PK. (2015)
From: Leishmania: Current Biology and Control
Chapter 6, pp 93-106, Eds. S. Adak and R. Datta, Caister Academic Press, Norfolk, UK.
Bioactive components of Licorice as an antileishmanial agent.
Gupta P, Ukil A and Das PK. (2016)
From: Research of Licorice in the Past, present and Future – Preparation of Various Bioactive Extracts as Alternative Medicines
Chapter 10, pp 147-163, Ed. Hiroshi Sakagami, INTECH
Leishmania exploits host’s defense machineries for survival: a tale of immune evasion.
Saha A and Ukil A. (2017)
From: Molecular Biology of Kinetoplastid Parasites
Ed. Majumder, H.K., pp107-120, Caister Academic Press, Norfolk, UK.
Anti-infectives to Combat Leishmaniasis
Roy, S., Ukil, A. and Das, P.K. (2021)
From: Frontiers in Clinical Drug Research – Anti-Infectives
Vol. 8, 1-36, Chapter 11. Bentham Books, Bentham Science Publishers
Heme Oxygenase 1: A potential drug target with multiple functions
Saha, S., Das, P.K. and Ukil, A. (2023)
From: Advances in Health and Medicine
Chapter 7, pages 149-164, Lowell T. Duncan (Ed), Nova Science Publishers, New York, USA.
Role of Apoptosis in Parasitic infections: Therapeutic targets and strategies
Das, T., Roy, S., Das, P.K. and Ukil, A. (2024)
Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential (Book Series)
Springer Nature publications, USA.
Anindita Ukil - University of Calcutta 